Impact of Time-Resricted Feeding and Aerobic Exercise Combination on Promotes Myokine Levels and Improve Body Composition in Obese Women

Abstract

Obesity has been proven to be the cause of various chronic diseases which can increase the risk of premature death. Changing lifestyle through diet and exercise is the best way to overcome the risk of obesity. This study aims to prove the effect of a combination of time-restricted feeding with moderate intensity aerobic exercise on increasing levels of myokines and improving body composition in obese women. A total of 28 obese women aged 20-30 years were involved in the study and were given time-restricted feeding (TRG) and time-restricted feeding and exercise (TREXG) interventions for 2 weeks. ELISA was used to measure PGC-1α and irisin levels in all samples, while TANITA DC-360 was used to measure body composition in the three groups TRG, TREXG, and the control group (CG). The results showed an increase in ∆PGC-1α between CG groups (0.25±2.29 ng/mL) vs TRG (1.64±3.56 ng/mL) vs TREXG (3.68±1.15 ng/mL) and p=0.031. ΔIrisin was also found to increase between CG (405.01±215.71 pg/mL) vs TRG (1443.92±1761.43 pg/mL) vs TREXG (3408.15±1299.85 pg/mL) and p=0.004. TREXG was found to have improved body composition compared to TRG and CG. The main finding of this study was an increase in myokines levels, namely levels of PGC-1α and irisin and there was an improvement in body composition in the time-restricted feeding and exercise group compared to the time restricted-feeding group and the control group in obese women. Keywords: Body composition, exercise, myokine, obesity, time-restricted feeding