Abstract
BackgroundThe incomplete repair (IR) model expresses the cell repair effect from radiation-induced damage over time, which is given little consideration in actual treatment planning. By incorporating the IR model into the normal tissue complication probability (NTCP), the accuracy and safety of treatment plan evaluations concerning the effect of repair can be improved. This study aims to evaluate the impact of incorporating the IR model into the NTCP by varying time-related factors such as the repair half-time (T1/2) and the junction-shift sc3hedule in craniospinal irradiation (CSI).MethodsCSI was planned retrospectively, and the NTCP of the spinal cord was calculated with the IR model for values of T1/2 from 1 to 10 h. The NTCP in the case of changing the junction-shift schedule was also examined in the same manner.ResultsThe NTCP with the IR model increased with increasing T1/2, which is prominent for the larger T1/2. By changing the junction-shift schedule, the NTCP with the IR model decreased when adjacent fields overlapped.ConclusionsThe IR model is a valuable addition to treatment planning because it enables the NTCP to be evaluated including the effect of repair and differences in scheduling to be reflected in the NTCP. However, these are largely dependent on the value of the T1/2.
Highlights
The incomplete repair (IR) model expresses the cell repair effect from radiation-induced damage over time, which is given little consideration in actual treatment planning
We examine the difference in the normal tissue complication probability (NTCP) of the spinal cord with the IR model for varying values of repair half-time
T1/2 dependence of NTCP considering IR model Figure 3 shows the NTCP as a function of T1/2 on the reference junction-shift schedules
Summary
The incomplete repair (IR) model expresses the cell repair effect from radiation-induced damage over time, which is given little consideration in actual treatment planning. By incorporating the IR model into the normal tissue complication probability (NTCP), the accuracy and safety of treatment plan evaluations concerning the effect of repair can be improved. To account for the cell repair effect, Oliver et al [2] proposed the time-based incomplete repair (IR) model, which was later modified by Levin-Plotnik et al [3], to include successive doses. By incorporating this model into the NTCP formula, the probability of complications, including the cell repair effect, can be estimated. Many authors have studied the cell repair effect, in
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