IMPACT OF THIAMINE DEFICIENCY IN SEPSIS HOSPITALIZATIONS

Abstract

SESSION TITLE: Sepsis: Beyond 30cc/kg and AntibioticsSESSION TYPE: Rapid Fire Original InvPRESENTED ON: 10/19/2022 11:15 am - 12:15 pmPURPOSE: Thiamine deficiency is a clinical disease that can result from severe prolonged deficiency of thiamine, it can affect the immune system resulting in weak immunity, the cardiovascular, and nervous system. In this study, we aim to study the impact of thiamine deficiency in Sepsis hospitalizations.METHODS: Hospitalizations with sepsis principal diagnosis on discharge were selected from the 2019 US National Inpatient Sample, using ICD 10 code (International Classification of Diseases, Tenth Revision, Clinical Modification). We queried the 2019 National Inpatient Sample for secondary diagnosis of thiamine deficiency. Confounders were adjusted for using multivariable logistic analysis.RESULTS: Among 2,245,305 adult hospitalizations with sepsis primary diagnosis on discharge, around 0.1% had a concomitant secondary diagnosis of thiamine deficiency, with mean age 61.3 years old in sepsis hospitalizations with thiamine deficiency, and 65.00 years old in sepsis hospitalizations without thiamine deficiency. 36.3% females in sepsis hospitalizations with thiamine deficiency vs 50% females without thiamine deficiency (p=0.001). Among sepsis hospitalizations 14% mortality rate in patients with thiamine deficiency vs 8.4% in patients without thiamine deficiency (p<0.001). An adjusted odds ratio of 2.05 for mortality in sepsis with thiamine deficiency compared to sepsis without thiamine deficiency (95% Confidence Interval [1.5 to 2.7]; p< 0.001). Sepsis hospitalizations with thiamine deficiency showed an increase in the mean length of stay by 6.95 days (95% Confidence Interval 5.5 to 8.4; p<0.001), and an increase in the mean of total hospitalization charges by $64,514 (95% Confidence Interval $38,353 to $90,678; p<0.001) compared to pneumonia hospitalizations without thiamine deficiency.CONCLUSIONS: Thiamine deficiency is associated with poor outcomes in patients with sepsis with a higher risk of in-hospital mortality, and increased hospital length of stay and health costs.CLINICAL IMPLICATIONS: This study points to the importance of identifying hospitalized patients with thiamine deficiency.DISCLOSURES: No relevant relationships by yazan Al JabiriNo relevant relationships by Mohannad Al-KhateebNo relevant relationships by Mohammad AldiabatNo relevant relationships by Rami DalbahNo relevant relationships by Ali HoroubNo relevant relationships by Tasnim Sholi SESSION TITLE: Sepsis: Beyond 30cc/kg and Antibiotics SESSION TYPE: Rapid Fire Original Inv PRESENTED ON: 10/19/2022 11:15 am - 12:15 pm PURPOSE: Thiamine deficiency is a clinical disease that can result from severe prolonged deficiency of thiamine, it can affect the immune system resulting in weak immunity, the cardiovascular, and nervous system. In this study, we aim to study the impact of thiamine deficiency in Sepsis hospitalizations. METHODS: Hospitalizations with sepsis principal diagnosis on discharge were selected from the 2019 US National Inpatient Sample, using ICD 10 code (International Classification of Diseases, Tenth Revision, Clinical Modification). We queried the 2019 National Inpatient Sample for secondary diagnosis of thiamine deficiency. Confounders were adjusted for using multivariable logistic analysis. RESULTS: Among 2,245,305 adult hospitalizations with sepsis primary diagnosis on discharge, around 0.1% had a concomitant secondary diagnosis of thiamine deficiency, with mean age 61.3 years old in sepsis hospitalizations with thiamine deficiency, and 65.00 years old in sepsis hospitalizations without thiamine deficiency. 36.3% females in sepsis hospitalizations with thiamine deficiency vs 50% females without thiamine deficiency (p=0.001). Among sepsis hospitalizations 14% mortality rate in patients with thiamine deficiency vs 8.4% in patients without thiamine deficiency (p<0.001). An adjusted odds ratio of 2.05 for mortality in sepsis with thiamine deficiency compared to sepsis without thiamine deficiency (95% Confidence Interval [1.5 to 2.7]; p< 0.001). Sepsis hospitalizations with thiamine deficiency showed an increase in the mean length of stay by 6.95 days (95% Confidence Interval 5.5 to 8.4; p<0.001), and an increase in the mean of total hospitalization charges by $64,514 (95% Confidence Interval $38,353 to $90,678; p<0.001) compared to pneumonia hospitalizations without thiamine deficiency. CONCLUSIONS: Thiamine deficiency is associated with poor outcomes in patients with sepsis with a higher risk of in-hospital mortality, and increased hospital length of stay and health costs. CLINICAL IMPLICATIONS: This study points to the importance of identifying hospitalized patients with thiamine deficiency. DISCLOSURES: No relevant relationships by yazan Al Jabiri No relevant relationships by Mohannad Al-Khateeb No relevant relationships by Mohammad Aldiabat No relevant relationships by Rami Dalbah No relevant relationships by Ali Horoub No relevant relationships by Tasnim Sholi