Impact of the intensity of conditioning regimen in 144 patients with follicular lymphoma (FL) receiving a matched unrelated donor stem cell transplant (MUD-SCT): An analysis from the Lymphoma Working Party of the European Group for Blood and Marrow Transplantation (LWP-EBMT)

Abstract

7036 Background: Matched unrelated donor stem cell transplant (MUD-SCT) provides the only potentially curative option for patients with follicular lymphoma (FL) who fail conventional therapies and do not have a sibling donor. Methods: The data of 144 patients with FL treated with reduced-intensity conditioning (RIC: 93) or conventional myeloablative (CONV: 51) MUD-SCT between 1991 and 2005 and included in the EBMT registry are reported. Results: Median time from diagnosis to MUD-SCT was 46 months and the median number of previous treatment lines was 4, including an autograft in 47% of patients. RIC recipients were significantly older, with a longer interval from diagnosis to MUD-SCT and had failed a previous autograft more frequently than CONV recipients. Non-relapse mortality (NRM) at 3 years was 34% and 46% for the RIC and the CONV groups, respectively (p<0.001). No differences were found in the risk of recurrence according to the conditioning regimen. Patients receiving a RIC procedure had a significantly longer progression-free survival (3-year PFS: 43%) and overall survival (3-year OS: 49%) than CONV recipients (3-year PFS: 35% -p=0.004-; 3-year OS: 40% -p=0.001-). Conclusions: This study demonstrates that RIC-MUD results, even in heavily pre-treated populations, in a significantly prolonged PFS. No significant financial relationships to disclose.