Impact of the COVID-19 pandemic on quality of life and emotional wellbeing in patients with bone metastases treated with radiotherapy: a prospective cohort study

M. M. T. J. Bartels,H. M. Verkooijen,R. Gal,J. M. van der Velden,J. J. C. Verhoeff,J. J. Verlaan

doi:10.1007/s10585-021-10079-x

M. M. T. J. Bartels, H. M. Verkooijen + Show 4 more

Open Access

https://doi.org/10.1007/s10585-021-10079-x

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Abstract

Implementation of COVID-19 measures may have induced concerns about access and quality of health care for cancer patients with bone metastases, and it may have affected their quality of life. In this study, we evaluated the effect of the first COVID-19 lockdown on quality of life and emotional functioning of patients with stage IV cancer treated for painful bone metastases in the UMC Utrecht, the Netherlands. A COVID-19 specific questionnaire was sent to active participants in the Prospective Evaluation of interventional StudiEs on boNe meTastases (PRESENT) cohort, consisting of patients irradiated for metastatic bone disease. Patient reported outcomes (PROs) were compared with the last two PROs collected within the PRESENT cohort before the COVID-19 lockdown in the Netherlands on the 16th of March. For the 169 (53%) responders, median age at start of lockdown was 68 years (range 38–92) and 62% were male. Patients reported a statistically significant decrease in emotional functioning (83.6 to 79.2, P = 0.004) and in general quality of life score during the COVID-19 lockdown (72.4 to 68.7, P = 0.007). A steep increase in feeling isolated was reported (18% before and 67% during lockdown). This study has shown a strong increase in the experience of isolation and a decrease of emotional functioning and general quality of life during the COVID-19 lockdown in cancer patients with bone metastases. Due to the nature of the treatment of this patient population, efforts should be made to minimize these changes during future lockdowns.

Highlights

On March 16th 2020, the first official lockdown was announced in the Netherlands as a reaction on the outbreak of the SARS CoV-2 pandemic
To accommodate the increasing pressure on the health care system in The Netherlands, elective health care was postponed as much as possible. This included postponement of most oncologic care to minimize infection risk, as cancer patients are considered a high-risk patient population that would suffer severe complications when infected with SARS-CoV-2. [3, 4] national and local oncological health care protocols were modified to minimise the risk of transmission of the virus and maximize capacity for COVID-19 care. [8]
We evaluated the effect of societal COVID-19 measures on changes in quality of life and emotional functioning of patients with metastatic bone disease

Summary

Introduction

On March 16th 2020, the first official lockdown was announced in the Netherlands as a reaction on the outbreak of the SARS CoV-2 pandemic. To accommodate the increasing pressure on the health care system in The Netherlands, elective health care was postponed as much as possible. This included postponement of most oncologic care to minimize infection risk, as cancer patients are considered a high-risk patient population that would suffer severe complications when infected with SARS-CoV-2. This unprecedented situation is expected to have impacted the life of many patients with metastasized cancer: implementation of the COVID-19 measures may have induced concerns about their (access) to treatment and continuity of health care. We evaluated the effect of societal COVID-19 measures on changes in quality of life and emotional functioning of patients with metastatic bone disease

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