IMPACT OF SYSTEMATIC AND MULTIDISCIPLINARY EVALUATION OF FMD PATIENTS ON NUMBER OF NEWLY REVEALED FMD LESIONS AND COMPLICATIONS -POLISH ARCADIA-POL STUDY

Abstract

Objective: Analysis of large cohorts of FMD patients allowed to reevaluate fibromuscular dysplasia (FMD) as a systemic arteriopathy. The aim of this analysis is to evaluate to what extent systematic and multidisciplinary evaluation of FMD patients results in novel FMD findings and reveals newly diagnosed vascular complications Design and method: Out of 272 patients enrolled into ARCADIA-POL study since January 2015 (instituted on the basis of Polish-French collaboration) we present 192 patients with confirmed FMD in at least one vascular bed.. All patients underwent detailed clinical evaluation including ABPM, biochemical evaluation, biobanking, duplex Doppler of carotid and abdominal arteries and whole body angio-CT. All patients included in the study were evaluated by the multidisciplinary team including specialists in cardiology and hypertension, interventional cardiology, radiology, interventional radiology, neuroradiology and vascular surgery. Results: Systematic evaluation of all 192 FMD patients included into the study revealed new FMD lesions in 61 (31.9 %) patients. Newly diagnosed vascular complications were found in 46 (24.0%) patients and in 2 patients more than one new vascular complications were revealed. Newly diagnosed aneurysms were found in 45 (32.4%) of patients and in 13 (6.8%) patients more than one aneurysms were found (Table). In 35 (18.2 %) FMD patients significant RAS was diagnosed.(Table).Conclusions: Systematic and multidisciplinary evaluation of FMD patients reveals a high incidence of previously unknown FMD lesions and newly diagnosed vascular complications.