Abstract
In order to improve the mechanical properties of skin tissue incision, enhance laser absorption efficiency, further shorten healing time and reduce skin fibrosis tendency, this study investigated the effects of CMCS or SWCNT combined with 25 % BSA and 0.4 % ICG on laser tissue welding. Nd:YAG pulsed laser was used for wound closure test on live rats with an energy density of 67.3 J/cm2 and linear scanning of skin incisions. The effects of different types and concentrations of biological dressings on wound closure were tested at different sites. The results showed that biocompatible dressings containing CMCS and SWCNTs had a significant effect in promoting wound healing after laser welding. After laser welding, the tensile strength of the control group without CMCS or SWCNTs was only between 6.5 and 9.8 N/cm2, while that with CMCS reached as high as 26.5 N/cm2. Macroscopic morphology analysis showed that components such as CMCS and SWCNTs could significantly shorten healing time from 14 days to 9–10 days. Optical performance tests demonstrated that a combination of 5 %CMCS and 4 %SWCNTs can significantly increase skin's absorption coefficient for laser photons up to7-8 Lg-1cm−1 and reduce photon diffuse reflectance. HE and Masson staining revealed that when internalized by dressing containing 0.4 %SWCNTs, nanocarbon particles promoted collagen skeleton regeneration but increased fibrosis tendency after 14 days post-laser welding, resulting in unfavorable long-term healing outcomes. However, the combination of CMSC with SWCNTs can significantly improve incision mechanical properties, laser photon absorption rate, and shorten healing time while reducing scar proliferation tendencies.
Published Version
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