Impact of Stomach Deformability on PTV Coverage in Patients with Gastric MALTs Treated with Deep Inspiration Breath Hold (DIBH) and Daily CT-based Image-guided Radiation Therapy (IGRT)

Abstract

Patients with extranodal marginal zone lymphomas of the stomach (gastric MALTs) have excellent prognoses. DIBH with CT-based IGRT is used to minimize unwanted dose to heart and lungs. However, the stomach presents unique challenges for RT given its deformability, which may not be adequately compensated by standard 6-dimensional shifts. We conducted a dosimetry study to evaluate our hypothesis that DIBH, CT-based IGRT, and fasting after midnight may not be sufficient to compensate for stomach deformability. Patients included were treated with DIBH and had daily IGRT with cone-beam CTs (CBCTs). All patients were simulated in alpha cradles with arms up. The CTV consisted of stomach with a 1.0 to 1.5cm CTV to PTV margin. Patients were instructed to fast after midnight. CBCTs used for daily image guidance prior to RT were collected. The stomach was contoured on each CBCT and then overlayed on the simulation scan. The stomach volume outside the PTV was calculated both in absolute volume and as a percentage of daily stomach volume. The relative location of the volume of stomach outside the PTV was also recorded. Five patients with biopsy-proven gastric MALTs who received definitive dose RT were included. Patients were followed for at least 11 months (range: 11 - 20 mo.), and all achieved a complete pathological response. Seventy daily CBCTs were used in the analysis. Across all images, the daily stomach volume was smaller than the CTV by a mean 99.3cc (range: <305.3cc - >108.9cc). The mean volume of stomach outside the PTV was 7.8cc (range: 0 - 75.5cc). This represented 3.1% of the daily stomach volume (range: 0 - 18.7%). Per patient, the mean percent volume outside the PTV ranged from 0.4% to 6.9%. In 3 of the 5 patients, the percent volume outside the PTV was <2.5%. The stomach was most often anterior to the PTV (31.4% of images). Medial and posterior extensions were the next most frequent, representing 21.4% and 14.3% of images, respectively. Of all the daily stomach contours, 15.7% remained wholly within the PTV. DIBH with daily IGRT in patients with gastric MALTs may result in moderate underdosing of the stomach due to its deformability. Daily stomach volumes were different in size from the CTV, and patients had an average of 0.4% to 6.9% of stomach volume outside the PTV. Regions of decreased coverage were most frequently seen anteriorly. Future dosimetry studies may suggest non-isometric PTV expansions to better cover these areas.