Abstract
Safety concerns have been raised about the use of adjuvanted vaccines after kidney transplantation. We retrospectively analyzed 65 kidney transplant (KT) recipients who received ≥1 dose of influenza vaccine (pandemic or seasonal) during the 2009-2010 campaign. Participants were classified into 2 groups: those who received a squalene-based AS03- or MF59-adjuvanted vaccine ("adjuvanted vaccination" [AV] group, n=37) and those who exclusively received non-adjuvanted vaccines ("non-adjuvanted vaccination" [NAV] group, n=28). Primary outcomes included occurrence of biopsy-proven acute graft rejection (BPAR) and graft function at months 6 and 12 after vaccination. Patients were followed up until graft loss, death, or October 2010. Four episodes of BPAR occurred during post-vaccination follow-up, with no differences between the AV and NAV groups, in terms of cumulative incidence (5.4% vs. 7.1%, respectively; P=0.581), incidence rate (0.22 vs. 0.18 episodes per 1000 transplant-days; P=0.950), or occurrence of severe episodes (T-cell-mediated BPAR of grade ≥2a) (2.7% vs. 3.6%; P=0.680). No between-group differences were seen in graft function after vaccination. Adjuvanted influenza vaccination in KT recipients seems to be safe regarding graft outcome.
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More From: Transplant infectious disease : an official journal of the Transplantation Society
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