Abstract
ObjectivesThe aim of this study was to investigate somatic mutations in the D-loop of mitochondrial DNA (mtDNA) and their impact on survival in oral squamous cell carcinoma patients.Materials and MethodsSurgical specimen confirmed by pathological examination and corresponding non-cancerous tissues were collected from 120 oral squamous cell carcinoma patients. The sequence in the D-loop of mtDNA from non-cancerous tissues was compared with that from paired cancer samples and any sequence differences were recognized as somatic mutations.ResultsSomatic mutations in the D-loop of mtDNA were identified in 75 (62.5%) oral squamous cell carcinoma patients and most of them occurred in the poly-C tract. Although there were no significant differences in demographic and tumor-related features between participants with and without somatic mutation, the mutation group had a better survival rate (5 year disease-specific survival rate: 64.0% vs. 43.0%, P = 0.0266).ConclusionSomatic mutation in D-loop of mtDNA was associated with a better survival in oral squamous cell carcinoma patients.
Highlights
Oral cancer was reported to be the sixth most common cancer in the world with an estimated 400,000 newly diagnosed cases and 223,000 mortalities in 2008 [1,2]
Somatic mutations in the displacement loop (D-loop) of mitochondrial DNA (mtDNA) were identified in 75 (62.5%) oral squamous cell carcinoma patients and most of them occurred in the poly-C tract
Somatic mutation in D-loop of mtDNA was associated with a better survival in oral squamous cell carcinoma patients
Summary
Surgical specimen confirmed by pathological examination and corresponding non-cancerous tissues were collected from 120 oral squamous cell carcinoma patients. The sequence in the D-loop of mtDNA from non-cancerous tissues was compared with that from paired cancer samples and any sequence differences were recognized as somatic mutations
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