Abstract
Background Single-use (SU) technologies supply a number of values to any mode of bioprocessing, but can provide some specific and enabling features in continuous bioprocessing (CB) implementations [1-3]. Most every operation in a CB process train is now supported by a commercially available single-use, or at least hybrid, solution (Figure 1). First of all, many of the SU equipment and solutions being developed for batch bioproduction have the same or related application in CB systems. Examples here include simple equipment such as tubings and connectors, to more complex applications such as the cryopreservation of large working stock aliquots in flexible bioprocess containers (BPCs). The list of CB-supporting SU technologies being developed is large and growing.
Highlights
Single-use (SU) technologies supply a number of values to any mode of bioprocessing, but can provide some specific and enabling features in continuous bioprocessing (CB) implementations [1-3]
Advances designs in SU transfer tubing, manifold design and container porting supports creativity in process design. This is of particular value in designing a process with such demands as entirely new flow paths or lot designations, such for CB
From a variety of manufacturers there are a number of distinct approaches to motor/disposable impeller assembly linkages, tubing lines and connections
Summary
Single-use (SU) technologies supply a number of values to any mode of bioprocessing, but can provide some specific and enabling features in continuous bioprocessing (CB) implementations [1-3]. Results A SU advantage in process development is its supports of an open architecture approach and a number of hybrid designs. Such designs include combining reusable and single-use systems, or between divergent suppliers of particular equipment. In bioproduction, the many flexibilities of SU support a manufacturing platform of exceptional efficiency, adaptability, and operational ease.
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