Abstract
BackgroundAsian-specific single nucleotide polymorphism (SNPs) (rs3782886) is reported to be associated with myocardial infarction; sarcopenia is reported to be associated with coronary subclinical atherosclerosis. On the other hand, short stature has been revealed as an independent risk factor for cardiovascular disease. However, no studies have reported on the association between sarcopenia and short stature nor on the impact of rs3782886 on this association.MethodsSince reduced maximum voluntary tongue pressure against the palate (MTP) reflects one aspect of sarcopenia, we conducted a cross-sectional study of 537 community-dwelling elderly Japanese participants aged 60–89 years who had participated in a general health checkup in 2015. Short stature was defined as values at or under the 25th percentile, and reduced MTP was defined as the lowest tertile of the study population (<158.0 cm and <26.5 kPa for men, <145.0 cm and <24.1 kPa for women).ResultsIndependent of classical cardiovascular risk factors, short stature was revealed to be positively associated with reduced MTP. The adjusted-odds ratio (OR) and 95% confidence interval (CI) of reduced MTP for short stature was 1.87 (1.19, 2.94). We also found that independent of known cardiovascular risk factors, with the non-minor homo of rs3782886 taken as the reference group, the adjusted OR and 95% CI for short stature and reduced MTP of the minor homo allele were 3.06 (1.23, 7.63) and 3.26 (1.33, 8.03), respectively.ConclusionShort stature is independently associated with reduced MTP, with Asian-specific SNPs possibly playing an important role in this association.
Highlights
Asian-specific single nucleotide polymorphism (SNPs) is reported to be associated with myocardial infarction; sarcopenia is reported to be associated with coronary subclinical atherosclerosis
We evaluated the impact of short stature on reduced Maximum voluntary tongue pressure against the palate (MTP) and found a positive association between the two
We found that SNP rs3782886 with the minor homo (G/G) allele is positively associated with short stature
Summary
Asian-specific single nucleotide polymorphism (SNPs) (rs3782886) is reported to be associated with myocardial infarction; sarcopenia is reported to be associated with coronary subclinical atherosclerosis. No studies have reported on the association between sarcopenia and short stature nor on the impact of rs3782886 on this association. Asian-specific single nucleotide polymorphism (SNP) rs3782886 in breast cancer suppressor protein-associated protein (BRAP) is reported to be associated with a risk of myocardial infarction [1]. Another study reported that BRAP activates inflammatory cascades and increases the risk of carotid atherosclerosis [2]. Since Japanese individuals are known to have a short stature, and short stature may constitute an inflammatory disadvantage [3] and a risk of carotid atherosclerosis [4], SNP rs3782886 may be associated with short stature. Reduced maximum voluntary tongue pressure against the palate (MTP) is reported to be associated with sarcopenia [7, 8].
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