Impact of Sex on Survival and Neurologic Outcomes in Adults With In-Hospital Cardiac Arrest

Abstract

Data regarding the impact of sex on clinical outcomes in adults with in-hospital cardiac arrest (IHCA) have yielded conflicting results. We aimed to study the impact of female sex on mortality and poor neurologic outcomes in adults with IHCA. The study population included 680 consecutive patients hospitalized with IHCA who underwent ACLS-guided resuscitation from 2012 to 2018 at an academic tertiary medical center. The primary outcome of interest was in-hospital mortality. Secondary outcome of interest was favorable neurological outcome, defined as a Glasgow Outcome Score of 4 or 5. Of the 680 patients studied, 418 (61.5%) were men and 262 (38.5%) were women. Women had lower rates of coronary artery disease, previous myocardial infarction, and peripheral artery disease, and higher rates of chronic obstructive pulmonary disease and depression. Although location of cardiac arrest, initial rhythm, and duration of cardiopulmonary resuscitation were similar in both groups, women had lower rates of defibrillation. Rates of return of spontaneous circulation and receipt of targeted temperature management were similar in men and women. With respect to outcomes, women were noted to have significantly higher rates of in-hospital mortality (87.5% vs 78.0%; p = 0.001) and lower rates of favorable neurologic outcome (10.0% vs 15.8%, p = 0.030) compared with men. In multivariable analyses, female sex was independently associated with nearly two-fold higher rates of in-hospital mortality [odds ratio (OR) 1.93, 95% confidence interval (CI) 1.22-3.04, p = 0.005] and a trend toward lower rates of favorable neurologic outcome (OR 0.63, 95% CI 0.38-1.04, p = 0.071). In conclusion, in this prospective, contemporary registry of adults with IHCA, female sex was independently associated with nearly twofold higher rates of in-hospital mortality and a trend toward lower rates of favorable neurologic outcomes.