Abstract
Objectives:Nasal septal deviation (NSD) is a common dilemma which cause nasal obstruction. Septoplasty is usually accomplished to solve nasal obstruction in patients with NSD. NSD is related strongly with hypoxia. Hypoxic conditions increase oxidative DNA damage in cells. This study aimed to investigate the effect of septoplasty on the level of antioxidant agents in patients with marked NSD. Methods: Sixty-one patients who submitted to septoplasty were involved in our prospective investigation. Results: The difference between the pre- and postoperative levels of MDA and 8-OHdG/106 dG was statistically significant. Conclusions: Septoplasty is an elective surgery performed to prevent the decrease in quality of life due to nasal obstruction and frequent respiratory tract infections in patients with NSD. As seen in this study, septoplasty is an urgent surgery that should be performed urgently to prevent DNA damage in patients with NSD
Highlights
Nasal obstruction is an usual ailment of subjects applying to otorhinolaryngologists and the leading argument of nasal obstruction is nasal septal deviation (NSD) [1]
Septoplasty is an elective surgery performed to prevent the decrease in quality of life due to nasal obstruction and frequent respiratory tract infections in patients with NSD
There are many studies that shown the nasal obstructions could result to chronic hypoxia [3, 4]
Summary
Nasal obstruction is an usual ailment of subjects applying to otorhinolaryngologists and the leading argument of nasal obstruction is nasal septal deviation (NSD) [1]. ROS are intimately conjoined with DNA rupture and infrastructure alteration [7]. For this intention, the utilisation of any marker of DNA oxidation, such as 8-hydroxy-2 -deoxyguanosine [8-OHdG], to measure oxidative stress is of implication [8]. There is no study, as far as we are interested, about the effect of septoplasty on antioxidant condition in patients with major NSD. We accomplished this survey to sustain whether there is a relation between NSD and serum MDA and leukocyte 8-OHdG degrees before and after septoplasty
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