Impact of Sao2/Fio2 Delta Value on Mortality in Critically III Patients with ARDS and COVID-19 in Prone Position

Abstract

Introduction: The COVID 19 pandemic generated in December 2019 has come to change paradigms in terms of ventilatory support measures worldwide, continuous clinical monitoring allows timely decision making impacting mortality in patients with ARDS. Objective: To identify the relationship between the SO2/FiO2 delta and mortality in critically ill patients with ARDS and COVID-19 in prone position. Material and methods: Retrospective, observational, comparative, analytical study, where all patients who met the inclusion criteria were evaluated: under mechanical ventilation and prone position for acute respiratory failure secondary to SARS-CoV-2 infection, measuring the value of SO2/FiO2 before and after the change of position to prone position, also mortality was recorded. Results: A total of 74 patients were analyzed, 33 corresponding to the survivors and 41 to the non-survivors group. The median age was 53.5 ± 12.77, with a male predominance. The mean days of mechanical ventilation were 10.64 ±5.16. A ROC curve was also performed for D SaO2/FiO2 and survival (AUC 0.668, p=0.013) for predicting patient survival. Conclusion: Continuous clinical monitoring is necessary to optimize resources in the different hospital and out-of-hospital areas. D SO2/FiO2 can be very useful for the continuous monitoring and prognosis in COVID-19 critical patients.