Impact of ropivacaine epidural anesthesia on the values of BIS with propofol TCI

Abstract

Objective To investigate the impact and mechanism of ropivacaine epidural anesthesia on the values of bispectral index (BIS) in patients with gastrointestinal tumors when propofol target-controlled infusion (TCI).Methods 40 patients were randomly divided into the epidural saline group (GC) and epidural RPC Group (GR),after the success of epidural catheterization connection BIS,set the TCI propofol effect-site concentration 2.5 μg/mL to maintain anesthesia,epidural administration at 15 min before surgery,GC group with 0.9％ saline,GR group with 0.75％ of the RPC.The first dose was 10 ml,then 5 ml/h continuous epidural injection recorded the BIS values.Results Two awake group showed no significant difference in BIS values(P＞0.05),BIS 30 min after operation in group GC,group GR values by an average of 85.46,BIS average of 80.33 of GR group,BIS 80.19 for 60 min GC group,BIS 72.51 for GR group,BIS of patients in two groups significantly reduced (P＜0.05).Conelusion Ropivacaine epidural anesthesia significantly can reduce the BIS values with propofol TCI, enhance the depth of sedation.It may be appropriate to reduce the amount of propofol and inprove the safety of operation. Key words: Ropivacaine; Epidural; Target-controlled infusion of propofol