Impact of resveratrol-containing peptide nanospheres on retinoblastoma cells

Abstract

For exploring an effective treatment of retinoblastoma (Rb), which is a threat to children, we constructed Resveratrol-peptide nanospheres (RES-PN) drug delivery system. Y-79 and S0-Rb50 cells were cultured to test the antitumor ability of RES-PN nanocomposites. In physicochemical properties test, we found PN could prolong RES half-life by about 3 times, and the particle size of RES-PN was about 214.10±3.73 nm, which was higher than that of PN (201.85±3.41 nm). Meanwhile, the encapsulation efficiency and drug loading rate of RES-PN were 90.77±3.51% and 9.82±0.64%, respectively. In the cell test, we found that RES-PN could better kill Rb cells and reduce their viability and invasiveness. Meanwhile, RES may induce Rb cell apoptosis through a mechanism possibly related to the JAK2/STAT3 axis. Hence, RES-PN shows great potential in Rb therapy.