Abstract
To describe respiratory symptoms and pulmonary function among long-term survivors of non-small cell lung cancer (NSCLC), and their relationship to quality of life (QOL). Cross-sectional survey of disease-free, 5-year minimum survivors of NSCLC (n = 142; 54% women; average age, 71 years); the majority (74%) had received a lobectomy. Analysis included frequency of self-reported respiratory symptoms (cough, phlegm, wheezing, breathlessness) as measured by the American Thoracic Society questionnaire, pulmonary function findings from hand-held spirometry, and QOL (Short Form-36). Two thirds of survivors reported at least one respiratory symptom (mean, 1.3; SD, 1.2): 25% cough, 28% phlegm, 31% wheezing, and 39% dyspnea. Twenty-one percent reported that they spent most of the day in bed in the past 12 months because of respiratory symptoms. Average FEV(1) percentage predicted was 68% (SD, 23); 21% had < 50% predicted FEV(1). Based on spirometry results, 36% had a moderate/severe obstructive and/or restrictive ventilatory disorder. Survivors exposed to second-hand smoke (28%) were more than three times as likely to report respiratory symptoms. Respiratory symptom burden contributed to diminished QOL in several domains. The majority of these survivors experienced respiratory symptoms, and more than one third reported dyspnea, including one of five patients with seriously diminished pulmonary function. Symptom burden, rather than ventilatory impairment, contributed to diminished QOL. Further study is needed to determine the patterns and effective management of posttreatment respiratory symptoms on survivors of lung cancer.
Highlights
Title Impact of respiratory symptoms and pulmonary function on quality of life of long-term survivors of non-small cell lung cancer
Twenty-one percent reported that they spent most of the day in bed in the past 12 months because of respiratory symptoms
Respiratory symptom burden contributed to diminished quality of life (QOL) in several domains
Summary
Because of the lack of data describing lung cancer survivors, the primary purpose of this study was descriptive in nature. The specific aims of this report are to describe, in long-term survivors of NSCLC, the following: (1) the frequency, severity, and clustering of respiratory symptoms and characteristics of respiratory illnesses within the past year; (2) pulmonary function abnormalities and their relationship to symptoms; (3) the relationship of health status and disease/treatment variables to presence of respiratory symptoms; and (4) the relationship of respiratory symptoms and lung function findings to QOL
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