Impact of renal function on changes of plaque characteristics in non-intervened coronary segments after rosuvastatin treatment in patients with angina pectoris and hypertension

Abstract

Chronic kidney disease (CKD) is a major health problem which is associated with poor outcomes [1] and increased prevalence of coronary artery disease [2]. Plaque progression in patients with hypertension is associated with the formation of angiotensin II, proliferation and migration of vascular smooth muscle cell, activation and accumulation of inflammatory cells, promotion of oxidative stress and endothelial dysfunction [3]. However, few data are available about the relation between renal function and plaque changes in statin-treated patients with angina pectoris and hypertension.