Impact of renal function in patients with multi-vessel coronary disease on long-term mortality following coronary artery bypass grafting compared with percutaneous coronary intervention

Abstract

BackgroundComorbidities, such as diabetes, affect revascularization strategy for coronary disease. We sought to determine if the degree of renal impairment affected long-term mortality after percutaneous coronary intervention (PCI) compared to coronary artery bypass grafting (CABG) in patients with multi-vessel coronary disease (MVD). Methods and results8970 patients with MVD undergoing revascularization between 2004 and 2008, in two multi-center parallel PCI and CABG Australian registries were assigned to three groups based on their estimated glomerular filtration rate (eGFR) ≥60mL/min/1.73m2 (n=1678:839), 30–59mL/min/1.73m2 (n=452:226) and <30mL/min/1.73m2 (n=74:37). We used 2:1 propensity matching to compare 3306 patients undergoing primary CABG versus PCI. Shock, myocardial infarction (MI) <24h, previous CABG, valve surgery or PCI were exclusions. Long-term mortality (mean 3.1years) was compared with Cox-proportional hazard-adjusted modeling. Observed long-term mortality rates (CABG vs. PCI) were 4.5% vs. 4.3% p=0.84, 12.8% vs. 17.3% p=0.12, and 23.0% vs. 40.5% p=0.05 in the three strata, respectively. In patients with eGFR ≥60mL/min/1.73m2, long-term mortality between PCI and CABG (HR 0.99, 95% CI 0.65–1.49, p=0.95) was similar. However, amongst patients with eGFR 30–59mL/min/1.73m2, there was a significant mortality hazard with PCI (HR 2.00, 95% CI 1.32–3.04, p=0.001). In patients with eGFR <30mL/min/1.73m2, there was a trend for hazard with PCI (HR 1.66, 95% CI 0.80–3.46, p=0.17). ConclusionLong-term mortality in MVD patients with preserved renal function was very low and similar between PCI and CABG. However there was a long-term mortality hazard associated with PCI amongst patients with moderate renal impairment.