Abstract

Posttransplant renal dysfunction and cardiovascular risk factors can be a consequence of either direct or indirect adverse effects of current immunosuppressive regimes. Therefore, different safety profiles of immunosuppressive agents should be taken into account when evaluating their potential impact on long-term survival after heart transplantation. We focus on safety profiles of cyclosporine A (CsA), tacrolimus (Tac), mycophenolate mofetil (MMF) and rapamycin (Rapa) especially in terms of nephrotoxicity, glucose changes, hypertension and hyperlipidemia.

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