Abstract
Objectives To assess oxidative damage to DNA during lung cancer (LC) treatments. Design and methods Urinary levels of 8-oxoguanine (8-oxoGua) and levels of 8-oxo-2′-deoxyguanosine (8-oxodG) from urine and whole blood were determined in 36 non-cancer controls and 65 LC patients before any treatments. Samples were also obtained of LC patients during and after radiotherapy (RT, n = 33) and chemotherapy (CT, n = 16). Results Stage IV LC patients had higher urinary 8-oxoGua and 8-oxodG levels than patients with stage I–III disease ( p = 0.044 and p = 0.034, respectively). Urinary 8-oxodG levels increased during the first week of RT ( p < 0.001). Nuclear 8-oxodG increased during RT and 3 months after start of RT. Nuclear 8-oxodG levels also rose between the first two CT cycles ( p = 0.043), and urinary 8-oxodG levels during the sixth CT cycle ( p = 0.009). Conclusions Urinary DNA damage biomarker levels may be associated with LC stage. Both RT and CT increase the parameters of DNA oxidation.
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