Impact of radiobiological models on the calculation of the therapeutic parameters of Grid therapy for breast cancer

Abstract

Therapeutic advantages of Grid therapy have been demonstrated in several theoretical studies using the standard linear-quadratic (LQ) model. However, the suitability of the LQ model when describing cell killing at highly modulated radiation fields has been questioned. In this study, we have applied an extended LQ model to recalculate therapeutic parameters of Grid therapy. This study shows that incorporating the bystander effects in the radiobiological models would significantly change the theoretical predictions and conclusion of Grid therapy, especially at high dose gradient fields.