Abstract
Post-surgical infections are polymicrobial and it is an important cause of morbidity and mortality. The combination of ciprofloxacin plus metronidazole as well as several ß-lactum based regimens are commonly used regimens for the treatment of patients with such infections. Three hundred patients (age range 25-40 years) were taken from two teaching hospitals for interventional study. When patients were selected for appenditectomy or cholecystectomy, either ciprofloxacin plus metronidazole or cephalosporin plus metronidazole were given intravenously. The patients were then divided into 4 groups. Group I and Group II received drugs ciprofloxacin plus metronidazole and cephalosporin plus metronidazole in SSMC respectively and Group III and Group IV received drugs ciprofloxain plus metronidazole and cephalosporin plus metronidazole in DNMC respectively. There were 33 cases of infections out of total 300 study subjects. It was observed that in SSMC among ciprofloxacin plus metronidazole; the rate of infection was 10.6% and cephalosporin plus metronidazole group was 14.6% while that in DNMC the rate were 8% and 10.6% respectively. The overall rate of infection was 11%.
Highlights
Impact of prophylactic use of antimicrobials in abdominal surgery in two tertiary level hospitals 'HSDUWPHQWRI3KDUPDFRORJ\DQG7KHUDSHXWLFV6LU6DOLPXOODK0HGLFDO&ROOHJHDQG0LWIRUG+RVSLWDO'KDND %DQJODGHVK
The choice of an antibiotic depends on the expected spectrum of organisms likely to be encountered, the cost and local hospital policies, which are based on experience of local resistance trends (Koch, 2004)
The patients were divided into four groups: Group I received drugs ciprofloxacin plus metronidazole in SSMC, Group II received drugs cephalosporin plus metronidazole in SSMC, Group III received drugs ciprofloxacin plus metronidazole in DNMC and Group IV received drugs cephalosporin plus metronidazole in DNMC
Summary
The combination of ciprofloxacin plus metronidazole as well as several ß-lactum based regimens are commonly used regimens for the treatment of patients with such infections. Conventional therapeutic doses should be employed and prophylaxis should be employed only in situations of documented drug efficacy (Trevor, 2002) Prophylactic antibiotics exert their greater effect in clean–contaminated surgical procedures (Relman, 1982). The combination of ciprofloxacin/metronidazole as well as several β –lactum based regimens are among the commonly used regimens for the treatment of patients with such infections. The ciprofloxacin and metronidazole combination may be superior to β–lactum based therapeutic regimens in the treatment of intra-abdominal infections with regard to cure of infections no difference in mortality was found (Mathaiou, 2006). The choice of an antibiotic depends on the expected spectrum of organisms likely to be encountered, the cost and local hospital policies, which are based on experience of local resistance trends (Koch, 2004)
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