Impact of Prolonged Duration of Symptoms on Mental Health in Anterior Cervical Disectomy and Fusion Patients.

Abstract

Prolonged duration of symptoms is associated with worse pain and disability in patients undergoing anterior cervical discectomy and fusion (ACDF). Our study aims to determine the effect of symptom duration on severity of depression among ACDF patients. We retrospectively reviewed a prospective surgical database from 2006 to 2019 for primary, single, or multilevel ACDF. Patients missing the duration of symptom information or patient-reported outcome measures (PROMs) were excluded. PROMs included Patient Health Questionnaire-9, 12-Item Short Form Mental Component Score, and 12-Item Veterans RAND Mental Component Score and were collected at preoperative, 6-week, 12-week, 6-month, 1-year, and 2-year timepoints. The minimum clinically important difference (MCID) was calculated using the established values. Patients were categorized based on preoperative duration of symptoms as follows: <6 months, ≥6 months and <1 year, 1 to 2 years, and >2 years. Univariate analysis was done to determine differences in demographics and perioperative characteristics. Intergroup differences in PROMs and MCID achievement were evaluated using linear regression and logistic regression, respectively. Two hundred thirty-one ACDF patients included had a mean age of 49.6 years and most were male (61.0%) and nonobese (<30 kg/m2; 55.0%). The groups differed by their American Society of Anesthesiologists classification (P = 0.029), workers' compensation status (P = 0.022), and diagnosis of herniated nucleus pulposus (P = 0.010). Postoperative mental health outcomes did not significantly differ between duration groups except for Veterans Rand-12 Mental Component Score at 12 weeks (P = 0.044). MCID achievement rates did not significantly differ. Patients undergoing ACDF largely did not demonstrate differences in mental health scores or achievement of MCID based on the duration of symptoms.