Abstract
Psoriatic arthritis (PsA) is a chronic condition characterized by a diverse set of symptoms, from swollen joints to nail disease to skin disease. A variety of treatment options are available, including tumor necrosis factor inhibitors (TNFis). Little is known about treatment persistence in patients with PsA who initiate TNFi therapy, with and without prior biologic use. This study assessed persistence in these subgroups of patients with PsA and identified factors associated with persistence. This retrospective study utilized data from the Corrona registry of patients with PsA—with or without prior biologic experience—who initiated TNFi therapy between October 1, 2002, and March 21, 2013. Kaplan-Meier curves estimated median time to nonpersistence (discontinuation or switch to another biologic). Cox proportional hazards models identified factors associated with TNFi nonpersistence. A total of 1241 TNFi initiations were identified: 549 by biologic-naïve and 692 by biologic-experienced patients. Through 4 years of follow-up, more biologic-naïve than biologic-experienced patients remained persistent. Biologic-naïve patients had a greater mean time to nonpersistence compared with biologic-experienced patients: 32 vs 23 months (p = 0.0002). Moderate and high disease activities based on clinical disease activity index and disease duration were associated with persistence in both biologic-naïve and biologic-experienced patients. Additionally, in the biologic-experienced patients, the number of prior medications and skin disease were associated with persistence. The majority of patients with PsA in this study were persistent with their TNFi therapy; biologic-naïve patients had greater persistence compared with biologic-experienced patients. Predictors of persistence differed slightly between biologic-naïve and biologic-experienced patients.
Highlights
Psoriatic arthritis (PsA) is an increasingly common chronic systemic inflammatory disease that affects both the skin and the musculoskeletal system [1,2,3]
Treatment persistence and prior biologic use are well documented in patients with rheumatoid arthritis (RA) and psoriasis; less is known about persistence in patients with PsA [8,9,10,11,12,13,14]
Patients from the Corrona registry were included in this study if they had a physician-recorded diagnosis of PsA; initiated therapy with a tumor necrosis factor inhibitors (TNFis) between October 1, 2002, and March 21, 2013; and were at least 18 years of age
Summary
Psoriatic arthritis (PsA) is an increasingly common chronic systemic inflammatory disease that affects both the skin and the musculoskeletal system [1,2,3]. Treatment options for PsA include nonsteroidal antiinflammatory drugs (NSAIDs), nonbiologic disease-modifying antirheumatic drugs (nbDMARDs), biologic agents (including tumor necrosis factor inhibitors [TNFis]), and small molecules Treatment persistence and prior biologic use are well documented in patients with RA and psoriasis; less is known about persistence in patients with PsA [8,9,10,11,12,13,14]. Factors associated with persistence differ based on prior biologic experience. The current study was undertaken to address this knowledge gap by describing persistence with TNFi in patients with PsA and to identify predictors of persistence, including the role of prior biologic use. This study provides a better understanding of the factors that influence discontinuation and switching of medications among patients with PsA with different biologic experience
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