Abstract
Impact of previous anti-angiogenesis treatment in nivolumab-treated advanced non-small cell lung cancer
Highlights
Surgery and Wound Healing Complications: Discontinue in patients with wound dehiscence
Hemorrhage: Severe or fatal hemorrhage, hemoptysis, gastrointestinal bleeding, central nervous systems (CNS) hemorrhage, and vaginal bleeding are increased in Avastin- treated patients
Avastin is not indicated for patients with breast cancer that has progressed following anthracycline and taxane chemotherapy administered for metastatic disease
Summary
Sections or subsections omitted from the Full Prescribing Information are not listed. [See. The incidence of wound healing and surgical complications, including serious and fatal complications, is increased in Avastin-treated patients. Avastin for at least 28 days after surgery and until the surgical wound is fully healed. Avastin is indicated for the first- or second-line treatment of patients with metastatic carcinoma of the colon or rectum in combination with intravenous 5-fluorouracil–based chemotherapy. Avastin is indicated for the first-line treatment of unresectable, locally advanced, recurrent or metastatic non–squamous non–small cell lung cancer in combination with carboplatin and paclitaxel. Avastin is indicated for the treatment of patients who have not received chemotherapy for metastatic HER2-negative breast cancer in combination with paclitaxel. Avastin is not indicated for patients with breast cancer that has progressed following anthracycline and taxane chemotherapy administered for metastatic disease
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