Impact of post-meal and one-time daily exercise in patient with type 2 diabetes mellitus: a randomized crossover study

Daizy Pahra,Sandhya Ghai,Anil Bhansali,Shobhit Bhansali,Nitasha Sharma,Abhishek Hajela

doi:10.1186/s13098-017-0263-8

Daizy Pahra, Sandhya Ghai + Show 4 more

Open Access

https://doi.org/10.1186/s13098-017-0263-8

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Abstract

BackgroundTo evaluate the effectiveness of short-timed post-meal and one-time daily exercise on glycemic control in patients with T2DM.MethodsSixty-four T2DM patients were randomised into crossover design. Group A (n = 32) underwent post-meal exercise (moderate-intensity brisk walking covering 1500–1600 steps for 15 min, starting 15 min after each meal) from d1 to d60 followed by one-time daily exercise (45 min pre-breakfast brisk walking at stretch covering 4500–4800 steps) from d61 to d120, while it was vice versa for the group B (n = 32). The five-point blood glucose profile was performed on d1, d30, d60, d90 and d120, and HbA1c on d1, d60 and d120. Fitness wrist band was used for step-counting to ensure the intensity of exercise and compliance to exercise protocol.ResultsGroup A patients showed a significant improvement in five point blood glucose profile and HbA1c after performing post-meal exercise (p < 0.001), which was mitigated after switchover to one-time daily exercise (p < 0.001). While, group B patients showed improvement in glucose profile and HbA1c (p < 0.001) after performing post-meal exercise, as compared to one-time daily exercise. Further, on pooled analysis (post-meal versus one-time daily exercise group) the beneficial effect of post-meal exercise on glucose profile and HbA1c was consistent as compared to one time daily exercise and the significance persisted on comparison between the two groups. No hypoglycemic events were noted between the groups during the study period.ConclusionPost-meal exercise is more effective than routine one-time daily exercise for glycemic control in T2DM patients.

Highlights

Though today’s fast paced world of urbanisation and technology has eased and reduced many of our laborious activities, it has been at the cost of rising prevalence of non-communicable diseases including obesity, metabolic syndrome, diabetes mellitus and hypertension
Post-meal physical activity may help in greater reduction in post-prandial hyperglycemia (PPH), and may reduce the CV risk more effectivly, than overall glycemic control
The effect of post-meal exercise on postprandial glycemic excursion in Type 2 diabetes mellitus (T2DM) was first shown by Larsen et al They demonstrated decrease in postprandial glycemic excursions after post-breakfast exercise, the benefit did not persist during and following the lunch [8]

Summary

Introduction

Though today’s fast paced world of urbanisation and technology has eased and reduced many of our laborious activities, it has been at the cost of rising prevalence of non-communicable diseases including obesity, metabolic syndrome, diabetes mellitus and hypertension. Type 2 diabetes mellitus (T2DM) currently accounts for majority of the world-wide burden of non-communicable diseases [1]. Current recommendations for patients with T2DM include walking or physical activity of similar intensity for at least 150 min/ week, is to be performed for meaningful reduction in HbA1c [5], improvement in cardiovascular risk profile. Post-meal physical activity may help in greater reduction in post-prandial hyperglycemia (PPH), and may reduce the CV risk more effectivly, than overall glycemic control. To evaluate the effectiveness of short-timed post-meal and one-time daily exercise on glycemic control in patients with T2DM

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Conclusion