Abstract
The serotonin transporter plays an important role in serotonergic neuromodulation. It is known that polymorphisms in the serotonin transporter gene are linked to the dysregulation of emotions. In the current study, we aimed to investigate the impact of variation in the gene encoding serotonin transporter polymorphism on oscillatory dynamics during inhibition of planned movement in the stop signal paradigm. During performance the stop signal paradigm, electroencephalograms (EEGs) were recorded in 90 healthy Caucasian children (39 girls) from 7 to 12 years. Buccal epithelium probes were taken from all participants. The La, Lg, and S alleles of serotonin transporter-linked polymorphic region (5-HTTLPR) polymorphism were detected in the DNA samples using PCR. LaLa genotype carriers did not differ from LaS\\LgS and LgS\\LgLg\\SS carriers in a number of successful inhibitions of a prepotent response. Carriers of LaLa exhibit higher alpha and beta event-related spectral perturbations (ERSP) in parietal and occipital cortices after the presentation of signal of inhibition of movement than LaS\\LgS and LgS\\LgLg\\SS carriers. Results are consistent with current literature and confirm that S allele carriers are more predisposed to disturbances in cognitive control.
Highlights
In recent years, a particular polymorphism in the serotonin transporter has attracted a lot of attention from researchers
The aim of the current study is to investigate the effect of the 5-HTTLPR gene polymorphism on oscillatory dynamics during successful inhibition of motor reaction in the stop signal paradigm in healthy children
The genotype groups did not differ in the level of neuroticism, extraversion, disagreeableness, and openness, which were measured using the Inventory of Child Individual Differences (ICID) [40]
Summary
A particular polymorphism in the serotonin transporter has attracted a lot of attention from researchers. The serotonin transporter has a great importance in serotonergic neuromodulation, which is strongly linked to mood, emotion, and regulation of cognition [1]. The serotonin gene is located on chromosome 17q12, and encoded by gene SLC6A4. The transcription of gene SLC6A4 is modulated by two polymorphisms, resulting in the long (L) and short (S) variants of the gene [2]. The S allele is linked to a lower level of RNA transcription compared with the L allele. The La allele is associated with a higher transcriptional efficiency, whereas Lg allele is connected to lower transcriptional efficiency and is similar to the S allele [3]
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