IMPACT OF POLYCYSTIC OVARIAN SYNDROME (PCOS) ASSOCIATED WITH HYPERTENSION ON SOME METABOLIC MARKERS

Abstract

Objective: Polycystic ovary syndrome (PCOS) is a multifactorial syndrome, including the hyper androgenism, ovulatory disorders with a polycystic appearance of the ovaries. PCOS is a disorder metabolic associated with an increased risk of insulin resistance, hyper insulinemia, central obesity, high blood pressure, type 2 diabetes, dyslipidemia and cardiovascular disease. Variability of sound expression and the difficulty of defining it with precision hamper the visibility of this affection, both in the population general than in a number of clinical situations. Several studies have highlighted an HTA in obese patients with PCOS. The objective of our work consists in studying the impact of the HTA and PCOS association on the disturbances of the metabolism (hepatic, lipid and renal). Design and method: For this study, 26 hypertensive patients with this syndrome were selected, recruited from level of the Tlemcen teaching hospital, and 30 healthy women witnesses. After their consent, patients benefited a specific biochemical assessment of liver function (TGO transaminases, TGP), renal function (acid uric, creatinine, urea), and the lipid profile (total cholesterol, LDL, triglycerides). Results: A comparison of the results obtained in hypertensive and normotensive PCOS patients shown that there is a disturbance in hepatic metabolism, expressed by high levels of transaminases (TGO, TGP), kidney damage, due to increased creatinine and urea, with lipidogram disturbance in hypertensive women with PCOS compared to women witnesses. Conclusions: In conclusion, PCOS associated with hypertension is the source of many dysfunctions metabolic (dyslipidemia, kidney and liver damage). For this, the dietary management and drug treatment of this syndrome is a strategy to reduce complications associated metabolic.