Abstract
Among DC subsets, the reconstitution of the natural type I-interferon-producing plasmacytoid DCs (PDC) has been proposed to play a major role in establishing immune competence, given the capacity of PDCs to efficiently expand either specific cytotoxic T lymphocytes, or to promote regulatory T cells, contributing to an impaired immune response. Therefore, we investigated the impact of circulating PDCs measured at 3 months after RIC-allo-SCT, in 54 pts who received a RIC-allo-SCT from an HLA-identical sibling, in order to determine whether this could provide a convenient indicator for long term outcome.
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