Abstract
Plasma medicine utilizes the combined interaction of plasma produced reactive components. These are reactive atoms, molecules, ions, metastable species, and radiation. Here, ultraviolet (UV, 100–400 nm) and, in particular, vacuum ultraviolet (VUV, 10–200 nm) radiation generated by an atmospheric pressure argon plasma jet were investigated regarding plasma emission, absorption in a humidified atmosphere and in solutions relevant for plasma medicine. The energy absorption was obtained for simple solutions like distilled water (dH2O) or ultrapure water and sodium chloride (NaCl) solution as well as for more complex ones, for example, Rosewell Park Memorial Institute (RPMI 1640) cell culture media. As moderate stable reactive oxygen species, hydrogen peroxide (H2O2) was studied. Highly reactive oxygen radicals, namely, superoxide anion (O2•−) and hydroxyl radicals (•OH), were investigated by the use of electron paramagnetic resonance spectroscopy. All species amounts were detected for three different treatment cases: Plasma jet generated VUV and UV radiation, plasma jet generated UV radiation without VUV part, and complete plasma jet including all reactive components additionally to VUV and UV radiation. It was found that a considerable amount of radicals are generated by the plasma generated photoemission. From the experiments, estimation on the low hazard potential of plasma generated VUV radiation is discussed.
Highlights
In the past decades, atmospheric pressure plasma jets have been increasingly used for the new field of plasma medicine.1–5 The strongly non-equilibrium chemistry along with their physical properties of energy transfer into sensible surfaces makes them excellently suited for treatment of, e.g., chronic wounds.6–9 The energy dissipated within the plasma is transferred into thermal, chemical, electronic, and radiative energy, to name the most relevant examples
The present study focuses on the generation of reactive species by vacuum ultraviolet (VUV) light, emitted from the plasma jet
This study showed the impact of argon plasma jet VUV radiation on the generation of reactive species in biologically relevant solutions
Summary
Atmospheric pressure plasma jets have been increasingly used for the new field of plasma medicine. The strongly non-equilibrium chemistry along with their physical properties of energy transfer into sensible surfaces makes them excellently suited for treatment of, e.g., chronic wounds. The energy dissipated within the plasma is transferred into thermal, chemical, electronic, and radiative energy, to name the most relevant examples. Atmospheric pressure plasma jets have been increasingly used for the new field of plasma medicine.. The gas and plasma phase chemistry of these jets has been investigated quite thoroughly, and many processes have been already understood.. For the field of plasma medicine, a further diagnostic step is required: When biological systems are plasma treated, these systems usually require a liquid surrounding, such as cell culture medium for in vitro studies.. Under physiological conditions in vivo, a liquid environment nearly always surrounds living tissue. It is in this liquid surrounding that the reactive species generation processes have to be diagnosed and understood. The present study focuses on the generation of reactive species by vacuum ultraviolet (VUV) light, emitted from the plasma jet.
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