Impact Of Physical Exercise On Inflammation Markers Among Adolescents With Overweight/obese

Abstract

PURPOSE: Obesity-related metabolic risk factors in adolescents with overweight/obesity may be associated with systemic low-grade inflammation, and therefore we investigated whether a 6-month exercise training altered markers of inflammation. METHODS: Secondary analyses of a randomized controlled exercise-based intervention trial (September 2017 to December 2018). Adolescents aged 11 to 17 years with overweight/obese status and/or excess of adiposity (body fat >30%). The adolescents were randomly assigned to the following 4 groups for 6 months: (1) standard physical education lessons, as a control (CTRL); (2) high-intensity physical education class (HIPE); (3) low-to-moderate intensity physical education class (LIPE); (4) a combined group (PLUS group). Inflammatory markers and immune molecules including chemokines, cytokines, and growth factors were determined by cytokine antibody array. RESULTS: Of the 120 randomly assigned participants, 95 were included in the analysis. Serum inflammatory levels such as MIP-1b (CCL4), RANTES (CCL5), BCL (CXC13), Eotaxin (CCL11), PARC (CCL19), and FGF-6 (Fibroblast Growth Factor-6) decreased significantly in the HIPE and PLUS groups (p < 0.05), supporting the anti-inflammatory effect of these two training programs. CONCLUSIONS: Implementing a 6-month physical exercise program in overweight/obese adolescents, based on HIPE and PLUS groups, significantly change several circulating inflammatory levels. Interventions involving supervised physical exercise may reduce the associated effects of systemic low-grade inflammation, thus preventing the development of obesity-related metabolic diseases in adolescents with overweight/obesity. Study Registration: ClinicalTrials.gov registration (NCT02753231).