Abstract
ABSTRACT BACKGROUND AND OBJECTIVES: Adequate postoperative pain and renal colic control is critical for patients' recovery and to decrease hospitalization costs and the use of resources. So, this study aimed at evaluating hospitalization time of patients treated with parecoxib sodium versus other non-steroid anti-inflammatory drugs to manage postoperative pain of appendectomy or fractures and renal colic. METHODS: This is a retrospective data analysis of Brazilian private hospitals medical bills, including patients treated with non-steroid anti-inflammatory drugs to decrease post-appendectomy pain (n=1618), post orthopedic fracture pain (n=2858 and renal colic (n=6555), between January and June 2014. Mean hospitalization time was evaluated according to each group of drugs. Mean difference among groups was calculated by the Kruskal-Wallis method. RESULTS: Mean hospitalization time for patients submitted to appendectomy was 1.95 days with parecoxib versus 2.20 with other non-steroid anti-inflammatory drugs (p= 0.006). For patients submitted to orthopedic fracture surgery, mean time was 1.75 days with parecoxib versus 1.93 days with other anti-inflammatory drugs (p=0.008). Parecoxib has also significantly decreased hospitalization time for renal colic as compared to other drugs (25.2h versus 32.9h; p<0.001). CONCLUSION: Parecoxib sodium has provided shorter hospitalization time with possible decrease in use of resources and costs and should be considered a choice for such painful conditions.
Highlights
Postoperative pain (POP) is the unpleasant consequence of tissue injury and inflammatory responses, incurred as result of diseases, traumas and/or surgeries
For surgical patients intolerant to oral drugs or for those where they are contraindicated, there is the need for effective intravenous (IV) analgesia without adverse events (AE) associated to non-selective non-steroid anti-inflammatory drugs (NSAIDS) or opioids
Parenteral administration allows its use in case of postoperative nausea and vomiting[18], it is an option for acute pain management and does not have the AE profile associated to non-selective COX inhibitors[19]
Summary
Postoperative pain (POP) is the unpleasant consequence of tissue injury and inflammatory responses, incurred as result of diseases, traumas and/or surgeries. It is estimated that more than half the hospitalized patients need other adjuvant treatments to handle these events after opioid administration, in addition to longer hospitalization time and higher hospitalizationrelated costs[4] In light of this scenario, non-steroid anti-inflammatory drugs (NSAIDS) are to be highlighted as important tools to treat PO pain, due to their analgesic efficacy. This study aimed at evaluating hospitalization time (less than or equal to five days) between groups of patients treated with parecoxib sodium as compared to other nonselective IV NSAIDS (ketoprofen, ketorolac and tenoxicam) to manage POP associated to appendectomy or orthopedic surgeries and acute renal colic. This study aimed at evaluating hospitalization time of patients treated with parecoxib sodium versus other non-steroid anti-inflammatory drugs to manage postoperative pain of appendectomy or fractures and renal colic.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
