Abstract
BackgroundSeveral risk factors for pacemaker (PM) related complications have been reported. However, no study has investigated the impact of lead characteristics on pacemaker-related complications.Methods and ResultsPatients who received a new pacemaker implant from January 1997 to December 2011 were selected from the Taiwan National Health Insurance Database. This population was grouped according to the pacemaker lead characteristics in terms of fixation and insulation. The impact of the characteristics of leads on early heart perforation was analyzed by multivariable logistic regression analysis, while the impact of the lead characteristics on early and late infection and late heart perforation over a three-year period were analyzed using Cox regression. This study included 36,104 patients with a mean age of 73.4±12.5 years. In terms of both early and late heart perforations, there were no significant differences between groups across the different types of fixation and insulations. In the multivariable Cox regression analysis, the pacemaker-related infection rate was significantly lower in the active fixation only group compared to either the both fixation (OR, 0.23; 95% CI, 0.07–0.80; P = 0.020) or the passive fixation group (OR, 0.26; 95% CI, 0.08–0.83; P = 0.023).ConclusionsThere was no difference in heart perforation between active and passive fixation leads. Active fixation leads were associated with reduced risk of pacemaker-related infection.
Highlights
The pacemaker (PM) is standard therapy for bradyarrhythmias [1,2] and the population with implanted devices continues to grow [3], PM-related complications such as infection, and cardiac perforation will increase as well [4,5]
In the multivariable Cox regression analysis, the pacemaker-related infection rate was significantly lower in the active fixation only group compared to either the both fixation (OR, 0.23; 95% confidence intervals (CI), 0.07–0.80; P = 0.020) or the passive fixation group (OR, 0.26; 95% CI, 0.08–0.83; P = 0.023)
Heart perforation is a relatively rare PM-related complication with a reported incidence ranging from 0.09% to 1.2% in the literature [12], some studies have pointed out certain risk factors for heart perforation such as temporary pacemakers, steroid use within 7 days prior to implantation, and helical screws [13]
Summary
The pacemaker (PM) is standard therapy for bradyarrhythmias [1,2] and the population with implanted devices continues to grow [3], PM-related complications such as infection, and cardiac perforation will increase as well [4,5]. These complications result in prolonged hospitalization and increased costs, and accrue worse outcomes and mortality [6]. No study has investigated the impact of lead characteristics on pacemaker-related complications
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