Abstract
Background Inhalative administration of oxygen increases pulmonary blood flow by vasodilation. Currently, flow rate quantification using conventional two-dimensional phase-contrast MRI (PC-MRI) is not capable to study short-term effects due to averaging of flow information. The aim of this study was to examine the impact of oxygen supply on respiration-related flow rate variations by non-electrocardiographic triggered real-time phase-contrast MRI (PC-MRI) in patients after total cavo-pulmonary connection (Fontan).
Highlights
Inhalative administration of oxygen increases pulmonary blood flow by vasodilation
Aortic flow rate was elevated during expiration (4.8 ±5.5%) and decreased during inspiration (-2.9±8.7%) in relation to mean blood flow, highest flow was detected during inspiration in inferior vena cava (IVC) (81.1±55.3%) and superior vena cava (SVC) (18.6 ±30.8%) and lowest flow during expiration (IVC:-85.7 ±56.9%,P
Differences were unchanged under oxygen supply in ascending aorta (AAo) (4.4±5.8%,3.4±8.6%,n.s.) and SVC (25.3±32.7%,18.8±33.4%,n.s.), whereas were slightly elevated in IVC (94.5±66.3%,98.0±69.0%)
Summary
Inhalative administration of oxygen increases pulmonary blood flow by vasodilation. Flow rate quantification using conventional two-dimensional phase-contrast MRI (PC-MRI) is not capable to study short-term effects due to averaging of flow information. The aim of this study was to examine the impact of oxygen supply on respiration-related flow rate variations by non-electrocardiographic triggered real-time phase-contrast MRI (PC-MRI) in patients after total cavo-pulmonary connection (Fontan)
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