Abstract
Diabetes mellitus is a group of metabolic disorders that share with symptoms of hyperglycemia led to elevated free radical activity. Hyperglycemia is linked to a higher level of (ADA), which is one of the factors that cause oxidative stress by creating reactive oxygen species (ROS), that leads to insulin resistance. This study aimed to determine the relationship between serum total adenosine deaminase(TADA) and its isoenzyme (ADA1and ADA2) with the progression of nephropathy in patients with type 2 diabetes using a case-control study from Wasit-Iraq. In addition, we aimed to find if there is a link between oxidative stress with TADA and its isoenzyme. The One-way ANOVA was used to compare the mean values of fasting plasma sugar (FPS), total oxidant status (TOS), total antioxidant status (TAS), malondialdehyde (MDA), microalbumin in urine, HbA1c, and TADA, ADA1, ADA2 between the three studied groups (Control(C), diabetic patients(DM), and diabetic nephropathy patient(DN). The results of our study revealed that there was a highly significant increase in TADA and its isoenzyme activities of DM and DN groups, as compared to the C group.
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