Abstract
The present study was designed to investigate the effect of lambda-cyhalothrin (LCH) on lipid peroxidation, oxidative stress biomarkers and the activity of Cytochrome P450 in male rats and the protective role of zinc. LCH was administrated orally to rats at dose 2.6 mg/kg b.wt. (Which represents 1/10 LD 50 ) with 3 doses per week for 6 weeks (dose period). Rats were divided into four groups, eight rats for, each: (I) control group, (II) zinc group (Zn dose 227 mg/l in drinking water), (III) LCH-treated groups and LCH-Zn group (IV) as in group II and III. The present results demonstrated that LCH induced significant alteration in the activity of antioxidant enzymes (superoxide dismutase, SOD; catalase, CAT; glutathione-s-transferase, GST; glutathione peroxidase, GPx), glutathione reduced (GSH) and lipid peroxidation (LPO) levels and decreased cytochrome P 450 (P 450 ) activity in plasma of male rats. In contrast, zinc-LCH treatment showed insignificant difference, compared to control results, regarding LPO, GST, CAT and P 450 . LCH induced oxidative stress, lipid peroxidation and reduced P450 activity in the plasma of male rats. The overall results reveal the pronounced ameliorating effect of zinc in LCH-intoxicated rats.
Highlights
Synthetic pyrethroids are a diverse class of more than thousand powerful broad spectrum insecticides that are environmentally compatible by virtue of their moderate persistence, low volatility and poor aqueous mobility in soil [1]
superoxide dismutase (SOD), CAT and Glutathione peroxidase (GPx) are known to play an important role in Plasma MDA level was markedly increased by LCH administration as compared to control group (Figure 1)
Co- administration of Zn to rats of LCH group alleviated lipid peroxidation induced by LCH in LCHtreatment and modulated significantly (1.92 nmoles of MDA/ml vs. 1.35 nmoles of MDA/ml, p ≤ 0.05) the levels of MDA in plasma compared to control
Summary
Synthetic pyrethroids are a diverse class of more than thousand powerful broad spectrum insecticides that are environmentally compatible by virtue of their moderate persistence, low volatility and poor aqueous mobility in soil [1]. They represent approximately onefourth of the worldwide insecticides market [2]. Endogenous H2O2 may be converted to H2O either by catalase or glutathione peroxidase (GSHPx). Otherwise, it may generate a highly reactive free hydroxyl radical (-OH) via a Fenton reaction, which is responsible for oxidative damage. Previous studies [10,11,14,15,16]reported that ROS were involved in the toxicity of various pesticides
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