Abstract
To assess the relation between oocytes yield including total retrieved oocytes (O)c and total mature oocytes (MII) relative to the antral follicular count (AFC) (3–9 mm in diameter) and relative to anti-müllerian hormone (AMH) ng/mL level: Oc/AFC, MII/AFC, Oc/AMH, and MII/AMH, respectively, and ART outcomes. We included retrospectively 264 IVF cycles after the first embryo transfer (ET) and after the cumulative ET (CET). The implantation rate (IR) and the live birth rate (LBR) after first ET were 31 ± 39% and 32.6%, respectively, and after CET 35 ± 38% and 45.1%, respectively. There was a significantly higher average of Oc/AFC and MII/AFC when live birth (LB) occurred after the first ET (0.82 ± 0.4 vs. 0.71 ± 0.35 and 0.57 ± 0.4 vs. 0.68 ± 0.3, respectively, P < 0.05). We reported a significantly higher average of MII/AFC when LB occurred after CET (0.66 ± 0.3 vs. 0.56 ± 0.30, P = 0.02) in comparison to the group where no LB was obtained. Increased Oc/AFC and MII/AFC ratios were associated with the occurrence of LB and increased IR after first ET (P < 0.05). Increased MII/AFC ratio was associated with the occurrence of LB and IR after CET (P = 0.02 and P = 0.04, respectively). After age-adjusted multivariate analyses, all these trends were confirmed (P < 0.05) except for the effect of MII/AFC ratio on IR after CET. In conclusion, Oc/AMH and MII/AMH ratios have no effect on the occurrence of LBR or on IR after first ET or CET at either age grouping. Ratios Oc/AFC and MII/AFC seem promising indicators to assess ovarian response.
Highlights
ART treatments are based on ovarian stimulation (OS), for which the use of gonadotropins remains essential
In an effort to determine whether Oc/antral follicular count (AFC), MII/AFC, Oc/anti-müllerian hormone (AMH), and MII/AMH ratio had an impact on the occurrence of live birth (LB) and on implantation rate (IR) in association with female age, we examined these 4 ratios using a bivariate age-grouping paradigm
Our study aimed to evaluate whether the calculation of an ovarian yield according to the number of retrieved oocytes or mature oocytes, previously described to assess ovarian response, was predictive of ART success
Summary
ART treatments are based on ovarian stimulation (OS), for which the use of gonadotropins remains essential. Retrospective analysis of a cycle of ovarian stimulation makes it possible to evaluate the ovarian response of each patient, even if this response may vary from one cycle to another. This is why some authors describe several categories of patients according to their response to ovarian stimulation: poor responders if they obtained
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