Abstract
BackgroundTo describe the health related quality of life in a population sample of postmenopausal women over the age of 50 and resident in the city of Valencia (Spain), according to the presence/absence of osteoporosis and the severity of prevalent morphometric vertebral fractures.MethodsA cross-sectional age-stratified population-based sample of 804 postmenopausal women of 50 years of age and older were assessed with the SF-12 questionnaire. Information about demographic features, lifestyle, clinical features, educational level, anti-osteoporotic and other treatments, comorbidities and risk factors for osteoporosis were collected using an interviewer-administered questionnaire and densitometric evaluation of spine and hip and spine x-rays were carried out.ResultsIn the non-adjusted analysis, mild and moderate-severe vertebral fractures were associated with decreased scores in the SF-12 Physical Component Summary (PCS) but not in the Mental Component Summary (MCS), while densitometric osteoporosis with no accompanying fracture was not associated with a worse health related quality of life. In multivariate analysis worse PCS scores were associated to the age groups over 70 (-2.43 for 70-74 group and -2.97 for 75 and older), chronic conditions (-4.66, -6.79 and -11.8 according to the presence of 1, 2 or at least 3 conditions), obesity (-5.35), peripheral fracture antecedents (-3.28), hypoestrogenism antecedents (-2.61) and the presence of vertebral fracture (-2.05).ConclusionsAfter adjusting for confounding factors, the physical components of health related quality of life were significantly lower in women with prevalent osteoporotic vertebral fractures than in women -osteoporotic or not- without vertebral fractures.
Highlights
Osteoporosis is a common condition characterized by decreased bone mass and increased susceptibility to fractures [1]
The specific instruments most widely used include the Osteoporosis Quality of Life Questionnaire (OQLQ) [6,7] and its reduced version the mini-OQLQ [8], the Quality of Life Questionnaire of the European Foundation for Osteoporosis (QUALEFFO) [9,10], the Osteoporosis Assessment Questionnaire (OPAQ) [11,12], the Osteoporosis-Targeted Quality of Life Questionnaire (OPTQoL) [13,14] and the assessment of health-related quality of life in osteoporosis (ECOS-16) [15]. Those most used in osteoporotic patients includes the EuroQol 5-D (EQ5D) [16,17], the Medical Outcomes Study Survey Form (MOS-SF) in its SF-12 [18] or SF-36 [16] versions that could be combined with the disease-specific module Quality of Life in Osteoporosis (QUALIOST) [19,20], and the Health Utility Index [7,21]
The aim of this study is to describe the Health Related Quality of Life (HRQoL) in a population sample of postmenopausal women of 50 years old and over and resident in the city of Valencia (Spain), according the presence/absence of osteoporosis and the severity of prevalent morphometric vertebral fractures
Summary
Osteoporosis is a common condition characterized by decreased bone mass and increased susceptibility to fractures [1]. Measures of Health Related Quality of Life (HRQoL) have gained increasing attention as relevant outcomes in clinical studies of osteoporosis [4,5]. The association with osteoporosis in the absence of fracture or with only mild morphometric fractures has been less studied. The aim of this study is to describe the HRQoL in a population sample of postmenopausal women of 50 years old and over and resident in the city of Valencia (Spain), according the presence/absence of osteoporosis and the severity of prevalent morphometric vertebral fractures. To describe the health related quality of life in a population sample of postmenopausal women over the age of 50 and resident in the city of Valencia (Spain), according to the presence/absence of osteoporosis and the severity of prevalent morphometric vertebral fractures
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