Impact of Non-small Cell Lung Cancer (NSCLC) Histology on Survival Predicted from the Graded Prognostic Assessment (GPA) for Patients with Brain Metastases

Abstract

The Graded Prognostic Assessment (GPA) provides a prognostic classification for patients with brain metastases, based on patient and tumor data from the RTOG database of randomized trials. Recent data suggest differential response and outcomes to selected chemotherapy for different NSCLC histologies. Using a large single institutional database of patients with brain metastases, we assessed the impact of histologic subtypes on survival outcomes stratified by the GPA.