IMPACT OF NON-SURGICAL PERIODONTAL THERAPY ON VISFATIN LEVEL IN GINGIVAL CREVICULAR FLUID OF TYPE II DIABETIC PATIENTS WITH PERIODONTITIS

Abstract

ckground: Visfatin was reported to exert various pro-inflammatory function. The present study aims to evaluate the level of visfatin in gingival crevicular fluid (GCF) and assess this relationship in individuals with diabetes mellitus type 2 (T2DM) and periodontitis (P) before and following nonsurgical periodontal therapy (NSPT). Patients and methods: Forty-five subjects were enrolled in this study and equally divided into three groups, group 1: healthy participants, group 2: patients with diabetes mellitus (T2DM) and periodontitis and group 3: patients with periodontitis only. Clinical parameters were recorded at baseline and after NSPT at 1, 3 and 6 months, visfatin levels were also assessed at the same time intervals using enzyme-linked immunosorbent assay. Results: GCF visfatin level at baseline showed a significantly lower concentration in healthy participants than in patients with periodontitis and T2DM and those with periodontitis only. A significant reduction in GCF visfatin level was observed in groups 2 and 3 following NSPT at 1, 3 and 6 months. Conclusion: The non-surgical periodontal therapy can significantly reduce GCF visfatin levels in patients with T2DM and periodontitis and those with only periodontitis. Furthermore, visfatin may be suggested as an inflammatory marker for periodontitis.