Abstract
BackgroundUremic neuropathy is a common complication in patients with end stage kidney disease. Its pathogenesis has been attributed to accumulation of uremic toxins. Kidney transplantation has been the best therapeutic option.Case presentationWe describe a case of severe uremic peripheral neuropathy, which improved after conversion from a conventional renal replacement therapy to nocturnal hemodialysis.ConclusionEnhanced uremic control by intensive hemodialysis may contribute at least in part to clinical and neurophysiological improvements of uremic neuropathy.
Highlights
Uremic neuropathy is a common complication in patients with end stage kidney disease
Uremic peripheral neuropathy is a common condition amongst patients with end stage kidney disease (ESKD), which in most cases is progressive, and in some significantly debilitating
Uremic neuropathy is a common condition in patients with ESKD
Summary
Uremic peripheral neuropathy is a common condition amongst patients with end stage kidney disease (ESKD), which in most cases is progressive, and in some significantly debilitating. Case Report A 48 year old man with ESKD presented with severe decreased sensation in his bilateral feet, originated from bottom of his feet, and gradually advanced to above the ankle level over the course of 2–3 years. He reported the sensation of “walking on cushions”, as well as progressive difficulty with ambulation. The rest of physical exam was unremarkable His initial laboratory testing showed abnormalities consistent with ESKD: blood urea nitrogen above 10 mmol/L and serum creatinine above 1000 umol/L, for the previous several years.
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