Impact of neonatal factors and nutrition on kidney size in 5-year-old preterm-born children.

Abstract

The aim of this article is to evaluate the influence of neonatal factors on kidney size in 5-year-old preterm-born children. Preterm-born children were examined at 5 years with kidney ultrasound. A total of 20 children were evaluated. Their gestational age (GA) was 29.3 ± 1.5 weeks, birth weight 1,321 ± 323 g. On Day 28, protein intake was (median, range) 2.8 (1.7-3.6 g/kg) g/kg, protein/total calories ratio 2.8 (range, 1.7-3.3 g/100 kcal) g/100 kcal. At 5 years, their systolic blood pressure was 97 mm Hg (range, 84-115 mm Hg). All had normal estimated glomerular filtration rate. Protein intake on Day 28 and protein/calories ratio on Day 28 were associated with a low total relative renal volume, respectively, β = - 37 ± 15, p = 0.03; β = - 50 ± 19, p = 0.03, after adjustment on GA, neonatal morbidities, and body mass index (multivariate linear regression). Kidney size was not associated with protein intake at 5 years. Improving protein prescription in the neonatal period could have an impact on kidney size in childhood in preterm-born children.