Abstract
Background and purposeIn locally advanced prostate cancer (PC), androgen deprivation therapy (ADT) in combination with whole prostate radiotherapy (RT) is the standard treatment. ADT affects the prostate as well as the tumour on multiparametric magnetic resonance imaging (MRI) with decreased PC conspicuity and impaired localisation of the prostate lesion. Image texture analysis has been suggested to be of aid in separating tumour from normal tissue. The aim of the study was to investigate the impact of ADT on baseline defined MRI features in prostate cancer with the goal to investigate if it might be of use in radiotherapy planning.Materials and methodsFifty PC patients were included. Multiparametric MRI was performed before, and three months after ADT. At baseline, a tumour volume was delineated on apparent diffusion coefficient (ADC) maps with suspected tumour content and a reference volume in normal prostatic tissue. These volumes were transferred to MRIs after ADT and were analysed with first-order -and invariant Haralick -features.ResultsAt baseline, the median value and several of the invariant Haralick features of ADC, showed a significant difference between tumour and reference volumes. After ADT, only ADC median value could significantly differentiate the two volumes.ConclusionsInvariant Haralick -features could not distinguish between baseline MRI defined PC and normal tissue after ADT. First-order median value remained significantly different in tumour and reference volumes after ADT, but the difference was less pronounced than before ADT.
Highlights
Prostate cancer is one of the most common cancers among men
A significant difference in apparent diffusion coefficient (ADC) between tumour at baseline and tumour after androgen deprivation therapy (ADT) was found for the first-order features for Mean, Me dian, Max, Standard deviation, and 95%-percentile
For the reference volume of interest (VOI) in ADC, a significant difference was found between baseline and after ADT, for the features Mean, Median, Max, 5%percentile, and 95%-percentile
Summary
Prostate cancer is one of the most common cancers among men. For locally advanced prostate cancer, androgen deprivation therapy (ADT) is a standard treatment in combination with whole prostate radio therapy (RT). Studies have shown that local recurrences often appear at or close to a dominant prostatic lesion [5,6] It has, been sug gested that tumour volumes within the prostate should be targeted with dose escalation, boosting, delivered with a dose-painting technique [7]. A tumour volume was delineated on apparent diffusion coefficient (ADC) maps with suspected tumour content and a reference volume in normal prostatic tissue. These volumes were trans ferred to MRIs after ADT and were analysed with first-order -and invariant Haralick -features. Results: At baseline, the median value and several of the invariant Haralick features of ADC, showed a significant difference between tumour and reference volumes. First-order median value remained significantly different in tumour and reference volumes after ADT, but the difference was less pronounced than before ADT
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