Abstract
BackgroundMonocyte to high-density lipoprotein cholesterol ratio (MHR) is a novel inflammatory marker that has been used to predict various inflammation-related diseases. This study aims to explore the association between MHR and prevalent hyperuricemia in a rural Chinese population.Methods8163 eligible participants (mean age: 54.13 years, males: 45.71%) from northeast China were enrolled in this cross-sectional study between 2012 to 2013. MHR was determined as blood monocyte count ratio to high-density lipoprotein cholesterol concentration.ResultsThe prevalence of hyperuricemia was 12.86%. After adjusting for potential confounding factors, per SD increase of MHR caused a 25.2% additional risk for hyperuricemia, and the top quartile of MHR had an 82.9% increased risk for hyperuricemia compared with the bottom quartile. Additionally, smooth curve fitting and subgroup analyses showed a linear and robust association between MHR and prevalent hyperuricemia respectively. Finally, after introducing MHR into the established model of risk factors, the AUC displayed a significant improvement (0.718 vs 0.724, p = 0.008). Furthermore, Category-free net reclassification improvement (0.160, 95% CI: 0.096–0.224, P < 0.001) and integrated discrimination improvement (0.003, 95% CI: 0.002–0.005, P < 0.001) also demonstrated significant improvements.ConclusionsThe present study suggests that MHR was positively and independently correlated with prevalent hyperuricemia among rural Chinese adults. Our results also implicate an important value for MHR in optimizing the risk stratification of hyperuricemia.
Highlights
Monocyte to high-density lipoprotein cholesterol ratio (MHR) is a novel inflammatory marker that has been used to predict various inflammation-related diseases
Chronic inflammation is a pathophysiological process characterized by elevated inflammatory mediators which closely associate with hyperuricemia [7, 8]
When dividing MHR into quartiles, we could observe the top quartile had an 82.9% increased risk for hyperuricemia compared with the bottom quartile in the fully adjusted model
Summary
Monocyte to high-density lipoprotein cholesterol ratio (MHR) is a novel inflammatory marker that has been used to predict various inflammation-related diseases. This study aims to explore the association between MHR and prevalent hyperuricemia in a rural Chinese population. The Mendelian randomization study supported that hyperuricemia may play a causal role in the development of CVD, suggesting its great significance for early screening and prevention of CVD [5]. Chronic inflammation is a pathophysiological process characterized by elevated inflammatory mediators which closely associate with hyperuricemia [7, 8]. Previous studies have shown that hyperuricemia might induce inflammation by activating the expression of inflammatory mediators [10, 11]. These studies indicated that hyperuricemia was closely related to inflammation
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
