Abstract
The aim of this mini review was to report the molybdenum compound intervention to control cancer disease. The intervention explains its roles and progress from inorganic molybdenum compounds via organomolybdenum complexes to its nanoparticles to control oesophageal cancer and breast cancer as case studies. Main contributions of molybdenum compounds as anticancer agents could be observed in their nanofibrous support with suitable physicochemical properties, combination therapy, and biosensors (biomarkers). Recent areas in anticancer drug design, which entail the uses of selected targets, were also surveyed and proposed.
Highlights
Drugs used to control the increasing cancer are either cytotoxic or cytostatic [1]
According to Nair et al, biological applications of molybdenum complexes were due to the ability of incorporated ligands to chelate with trace metal ion, their rare action mechanisms, and capability to produce a high amount of harmful reactive oxygen species (ROS) which can interrupt the redox balance of a system leading to increase in deoxyribonucleic acid (DNA) damage, DNA protein cross-linked formation, lipid peroxidation, cellular toxicity, and/or wrong initiation of cellular signaling paths [8]
Combination therapy of molybdenum-based compounds and biomarkers cancers, Ndagi et al studied different types of very accurate and very sensitive NP-based imaging platforms because these platforms are more advantageous compared with other agents [28]. ese NPs can be functionalized to target accurately cancer and tumour cells, allowing the imaging and healing agents to be accurately delivered into these cells
Summary
Received 15 January 2019; Revised 24 April 2019; Accepted 30 May 2019; Published 10 September 2019. Drugs used to control the increasing cancer are either cytotoxic (cell killing) or cytostatic (cell stabilizing) [1]. Metalloelements in trace amounts execute important activities in the living system Among these metalloenzymes are transition metals, which represent the d block elements between Groups 3 and 12 in the periodic table [1]. E d block transition metals in the periodic table have partially filled electrons (d orbitals), which influence remarkable electronic properties when examined for the development and design of anticancer agents. E ability of ligands to coordinate metals in a threedimensional arrangement permits groups’ functionalization which can be designed to distinct molecular targets in the development of novel medicinal agents. In the clinics, cisplatin (platinum metal ammine) is a global cytotoxic drug for cancer treatment [1]. In order to improve the global anticancer study, comes the question, what impact does molybdenum play?
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