Abstract

Multiple sclerosis (MS) is a chronic disease, with fatigue syndrome as one of the main symptoms. The aim of this study was to demonstrate that moderate physical activity (MPA) may have a beneficial effect on postural stability, balance, and clinical parameters. The research group consisted of 137 randomized patients hospitalized at the Department of Neurological Rehabilitation, Medical University of Lodz. Finally, 76 patients were qualified who were divided into two groups—high fatigue (HF) and low fatigue (LF). Participants were assessed twice: before and after a 4-week MPA program using: the Expanded Disability Status Scale (EDSS), the Fatigue Severity Scale (FSS), the Mini-Mental State Examination (MMSE), the Montreal Cognitive Assessment (MoCA), the Beck Depression Inventory (BDI), and the Geriatric Depression Scale (GDS), and stabilometric platform tests were performed. Results obtained after the 4-week MPA program showed a positive effect of the MPA with differences between LF and HF groups. The MPA was more effective in MS patients with LF in cognitive functions, functional status, and postural stability but among HF patients in an emotional state, especially in MS patients below 65 years, although in total, both groups benefited from the MPA.

Highlights

  • Multiple sclerosis (MS) is a chronic heterogeneous disease with an unpredictable clinical course

  • Inclusion criteria for this study were: diagnosis of MS according to the McDonald criteria, age 18 years or older, Expanded Disability Status Scale (EDSS) score below 6, Mini-Mental State Examination (MMSE) > 15 and Montreal Cognitive Assessment (MoCA) > 10, diagnosis of fatigue syndrome based on Fatigue Severity Scale (FSS) score over 38, lack of relapses during the previous 3 months, and not receiving an moderate physical activity (MPA) training program in the last 6 months (Figure 1)

  • The results obtained after MPA showed a positive change in the emotional status of the MS patients

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Summary

Introduction

Multiple sclerosis (MS) is a chronic heterogeneous disease with an unpredictable clinical course. Patients with MS experience a wide range of symptoms, such as paralysis, ataxia, spasticity, incontinence, and fatigue syndrome. Fatigue is reported in 70–80% of patients and is considered one of the most prevalent and disabling symptoms in all stages of the illness [1]. This common kind of lassitude is unique to people with MS. It is called MS-related fatigue and is not associated with the level of disability or depression [2]. Body Height (cDma)ta for fatigue16w8e.5r0e(c1o6l3l.e4c5t–e1d75u.1s1in) g the Fatig1u70e.0S0ev(1e6r7i.t8y2–S1c7a2le.22(F) SS).

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