Impact of middle cerebral artery pulsatility index on donor survival in twin-twin transfusion syndrome.

Abstract

To assess outcomes in twin-twin transfusion syndrome (TTTS) according to middle cerebral artery pulsatility index (MCA-PI) prior to fetoscopic laser photocoagulation (FLPC) surgery. A retrospective cohort analysis of monochorionic-twin pregnancies complicated by TTTS who underwent FLPC at two fetal centers (2012-2021). The cohort was stratified according to abnormal MCA-PI of the donor twin, defined as below fifth centile for gestational age. Abnormal MCA-PI of the donor twin was detected in 46 (17.7%) cases compared to 213 (83.3%) controls with no such abnormality. The abnormal PI group presented with higher rates of sFGR (56.5% vs. 36.8% in controls, p=0.014) and lower donor survival rates within 48h after FLPC (73.9 vs. 86.8%, p=0.029). Donor twin survival rates at the time of delivery and 30days after birth were lower in the abnormal MCA-PI. Multivariate logistic regression analysis controlling for sFGR and MCA-PI <fifth centile demonstrated the latter to be independently associated with lower survival rates at the time of delivery and 30days after birth [OR=0.497 95%CI (0.250-0.986) p=0.045, and OR=0.499 95%CI (0.252-0.986), p=0.046, respectively]. Recipient's survival rates did not differ between the groups. Donor survival at the time of delivery and 30days after birth was lower in TTTS cases with MCA-PI<fifth centile for gestational age prior to laser surgery. This parameter may be considered when evaluating prognosis for TTTS.