Impact of methodological variability on EEG responses evoked by transcranial magnetic stimulation: A meta-analysis

Abstract

ObjectiveThis meta-analysis aimed to synthesize the existing literature on how different parameters of transcranial magnetic stimulation (TMS) and electroencephalogram (EEG) modulate the amplitudes of TMS-evoked potentials (TEPs). MethodsA comprehensive search was run in PubMed and completed by Google Scholar to find articles studying healthy participants who underwent single pulse TMS-EEG sessions over their left primary motor cortex (M1) or dorsolateral prefrontal cortex (DLPFC). The amplitudes of the most commonly investigated TEP peaks for DLPFC stimulation (positives: 25, 60, 185 ms, negatives: 40, 100 ms) and M1 stimulation (positives: 30, 55,180 ms and negatives: 15, 45, 100, 280 ms) were extracted from studies. ResultsCohen’s d effect sizes were obtained in five independent categories that were stratified based on the stimulation, recording, and analyzing parameters. The overall effect sizes and equivalent means and standard deviations were computed within every category. ConclusionsThis meta-analysis spotlights the need to rigorously and systematically control for the critical parameters in recording and analyzing TMS-EEG data to make the outcomes of further studies more comparable to the current body of literature. SignificanceThe study demonstrates the possibility of reliably measuring TEPs by offering approximate ranges for every TEP peak in the most commonly targeted areas of DLPFC and M1.